---
attrs:
  .reference_type: 0
  Abstract: 'Asthma is a disease characterized by intermittent bronchoconstriction due to increased airway reactivity to both allergic and nonallergic stimuli. Most asthma exacerbations that result in hospitalization are associated with viral upper respiratory tract infections. Such infections typically induce T-helper type 1 (T(H)1) responses in the airway, involving activation of nuclear factor-kappaB (NF-Kappa B). However, a more recently appreciated cause of asthma exacerbation is exposure to pollutants, including ozone and various components of particulate matter (PM), including transition metals, diesel exhaust, and biologicals such as endotoxin. Although the role of air toxics in asthma pathogenesis remains incompletely examined, many components of PM that are active exacerbants of asthma are also prominent air toxics (metal ions and organic residues). These agents have been observed to activate NF-Kappa B. Reviewed in this article are the actions of specific air pollutants on airway inflammation in humans and potential common response pathways for ozone, PM, and several air toxics.'
  Author: 'Peden, D. B.'
  Date: Aug
  ISSN: 1552-9924
  Journal: Environmental Health Perspectives
  Keywords: 'Air Pollutants/*adverse effects; Asthma/*etiology/immunology; Endotoxins/adverse effects; Humans; Inflammation/*physiopathology; Metals, Heavy/adverse effects; Organic Chemicals/adverse effects; Particle Size; Respiratory Tract Infections/complications/virology; T-Lymphocytes, Helper-Inducer/*immunology'
  Language: eng
  Notes: 'Peden, David B Journal Article Review United States Environ Health Perspect. 2002 Aug;110 Suppl 4:565-8.'
  PMC: 1241207
  Pages: 565-568
  Title: 'Pollutants and asthma: Role of air toxics'
  URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241207/pdf/ehp110s-000565.pdf
  Volume: 110 Suppl 4
  Year: 2002
  _record_number: 18267
  _uuid: f1f613d3-7788-4785-bb9b-f308b190e63e
  reftype: Journal Article
child_publication: /article/pmc1241207
description: 'Pollutants and asthma: Role of air toxics'
display_name: 'Pollutants and asthma: Role of air toxics'
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publications:
  - /report/usgcrp-climate-human-health-assessment-2016/chapter/populations-of-concern
  - /report/usgcrp-climate-human-health-assessment-2016
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