References in Pollutants and asthma: Role of air toxics

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reference : Pollutants and asthma: Role of air toxics

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/report/usgcrp-climate-human-health-assessment-2016/reference/f1f613d3-7788-4785-bb9b-f308b190e63e

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/reference/f1f613d3-7788-4785-bb9b-f308b190e63e
/report/usgcrp-climate-human-health-assessment-2016/chapter/populations-of-concern/reference/f1f613d3-7788-4785-bb9b-f308b190e63e
/report/usgcrp-climate-human-health-assessment-2016/reference/f1f613d3-7788-4785-bb9b-f308b190e63e

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article

Pollutants and asthma: Role of air toxics

Bibliographic fields
reftype	Journal Article
Abstract	Asthma is a disease characterized by intermittent bronchoconstriction due to increased airway reactivity to both allergic and nonallergic stimuli. Most asthma exacerbations that result in hospitalization are associated with viral upper respiratory tract infections. Such infections typically induce T-helper type 1 (T(H)1) responses in the airway, involving activation of nuclear factor-kappaB (NF-Kappa B). However, a more recently appreciated cause of asthma exacerbation is exposure to pollutants, including ozone and various components of particulate matter (PM), including transition metals, diesel exhaust, and biologicals such as endotoxin. Although the role of air toxics in asthma pathogenesis remains incompletely examined, many components of PM that are active exacerbants of asthma are also prominent air toxics (metal ions and organic residues). These agents have been observed to activate NF-Kappa B. Reviewed in this article are the actions of specific air pollutants on airway inflammation in humans and potential common response pathways for ozone, PM, and several air toxics.
Author	Peden, D. B.
Date	Aug
ISSN	1552-9924
Journal	Environmental Health Perspectives
Keywords	Air Pollutants/adverse effects; Asthma/etiology/immunology; Endotoxins/adverse effects; Humans; Inflammation/physiopathology; Metals, Heavy/adverse effects; Organic Chemicals/adverse effects; Particle Size; Respiratory Tract Infections/complications/virology; T-Lymphocytes, Helper-Inducer/immunology
Language	eng
Notes	Peden, David B Journal Article Review United States Environ Health Perspect. 2002 Aug;110 Suppl 4:565-8.
PMC	1241207
Pages	565-568
Title	Pollutants and asthma: Role of air toxics
URL	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241207/pdf/ehp110s-000565.pdf
Volume	110 Suppl 4
Year	2002

Bibliographic identifiers
.reference_type	0
_record_number	18267
_uuid	f1f613d3-7788-4785-bb9b-f308b190e63e