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reference : Traffic-related air pollution and childhood respiratory symptoms, function and allergies

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Traffic-Related Air Pollution and Childhood Respiratory Symptoms, Function and Allergies
Bibliographic fields
reftype Journal Article
Abstract Background: Urban air pollution can trigger asthma symptoms in children, but there is conflicting evidence on effects of long-term exposure on lung function, onset of airway disease and allergic sensitization. Methods: The spatial distribution of nitrogen oxides from traffic (traffic-NOx) and inhalable particulate matter from traffic (traffic-PM10) in the study area was assessed with emission databases and dispersion modeling. Estimated levels were used to assign first-year exposure levels for children in a prospective birth cohort (n = 4089), by linking to geocoded home addresses. Parents in 4 Swedish municipalities provided questionnaire data on symptoms and exposures when the children were 2 months and 1, 2, and 4-year-old. At 4 years, 73% of the children underwent clinical examination including peak expiratory flow and specific IgE measurements. Results: Exposure to air pollution from traffic during the first year of life was associated with an excess risk of persistent wheezing (odds ratio [OR] for 44 μg/m3 [5th–95th percentile] difference in traffic-NOx = 1.60; 95% confidence interval [CI] = 1.09–2.36). Similar results were found for sensitization (measured as specific IgE) to inhalant allergens, especially pollen (OR for traffic-NOx = 1.67; 95% CI = 1.10–2.53), at the age of 4 years. Traffic-related air pollution exposure during the first year of life was also associated with lower lung function at 4 years of age. Results were similar using traffic-NOx and traffic-PM10 as indicators. Conclusions: Exposure to moderate levels of locally emitted air pollution from traffic early in life appears to influence the development of airway disease and sensitization in preschool children.
Author Nordling, Emma Berglind, Niklas Melén, Erik Emenius, Gunnel Hallberg, Jenny Nyberg, Fredrik Pershagen, Göran Svartengren, Magnus Wickman, Magnus Bellander, Tom
DOI 10.1097/EDE.0b013e31816a1ce3
ISSN 1044-3983
Issue 3
Journal Epidemiology
Keywords 00001648-200805000-00011
Pages 401-408
Title Traffic-related air pollution and childhood respiratory symptoms, function and allergies
URL http://journals.lww.com/epidem/Fulltext/2008/05000/Traffic_Related_Air_Pollution_and_Childhood.11.aspx
Volume 19
Year 2008
Bibliographic identifiers
.reference_type 0
_chapter ["Ch. 9: Human Health FINAL","Overview"]
_record_number 4678
_uuid e05add6e-d140-48be-a2ff-1b070c5cc523