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reference : West Nile fever characteristics among viremic persons identified through blood donor screening
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/reference/a67e8ff1-028b-4ded-8f09-cabc0c870b12
/reference/a67e8ff1-028b-4ded-8f09-cabc0c870b12
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| reftype | Journal Article |
| Abstract | Nucleic acid testing (NAT) of blood donors provides opportunities for identifying West Nile virus (WNV)-infected persons before symptoms develop and for characterizing subsequent illness. From June 2003 through 2008, the American Red Cross performed follow-up interviews with and additional laboratory testing for 1436 donors whose donations had initial test results that were reactive for WNV RNA; 821 of the donors were subsequently confirmed to have WNV infection, and the remainder were unconfirmed or determined to have false-positive results. Symptoms attributed to WNV infection were determined by comparing symptom frequency among 576 donors identified with early WNV infection (immunoglobulin M antibody negative) and those with unconfirmed infection. We estimate that 26% of WNV-infected persons become symptomatic, defined by the presence of at least 3 of 8 indicator symptoms. Nearly one-half of symptomatic persons sought medical care; only 5% received a diagnosis of WNV infection. Female subjects and persons with higher viral loads detected in the index donation were more likely than other subjects to develop symptoms. |
| Author | Zou, S.; Foster, G. A.; Dodd, R. Y.; Petersen, L. R.; Stramer, S. L. |
| DOI | 10.1086/656602 |
| Date | Nov 1 |
| ISSN | 1537-6613 |
| Issue | 9 |
| Journal | The Journal of Infectious Diseases |
| Keywords | Adult; Aged; *Blood Donors; Female; Humans; Male; *Mass Screening; Middle Aged; RNA, Viral/*blood; United States; Viral Load; West Nile Fever/*diagnosis/*pathology; West Nile virus/*genetics |
| Notes | Zou, Shimian Foster, Gregory A Dodd, Roger Y Petersen, Lyle R Stramer, Susan L eng 2010/09/30 06:00 J Infect Dis. 2010 Nov 1;202(9):1354-61. doi: 10.1086/656602. |
| Pages | 1354-1361 |
| Title | West Nile fever characteristics among viremic persons identified through blood donor screening |
| Volume | 202 |
| Year | 2010 |
| .reference_type | 0 |
| _record_number | 18046 |
| _uuid | a67e8ff1-028b-4ded-8f09-cabc0c870b12 |
